2000, 2006 and 2021. Three trips, three stages of five lives. Jana, Luca, Roberto, Yoon Soo and Raquel are in their mid-20s / early 30s on their first two "Caminos", and past 40 on their third. So much will happen until then: Jana's anti-establishment rage will have calmed somewhat, revealing unexpected compassion in the German woman. Luca, the Italian, will hit rock bottom and resurrect himself with a little help from his friends. Roberto, the Mexican, will learn to forgive himself by accepting that another's death was not his fault. And while their passion for music makes Korean Yoon Soo and Spaniard Raquel the perfect couple, they must learn the hard way that they have mistaken friendship for love before they can once again find peace of mind. All of them experience friendship and loss, jealousy and love, courage and despair, forgiveness, bliss and finding their own personal purpose in life.