The story of Plus Two revolves around five teenagers. Prince is a 12th grade student who stays alone in a villa as his parents are abroad. A girl Meenakshi with the purpose of looking around for her sister Parvathy, arrives at the wrong address (Prince's house). The death of her mother causes him to sympathize on her and he decides to help her. As time passes, secrets are revealed, and changing situations force them to be more mature than their age demands.