Dani is a 23-year-old virgin on a mission to finally "do it", but her plans get squashed when she finds out she has a yeast infection. Convinced that losing her virginity is what she needs to move forward in life, she sets out to rid herself of the infection with the support of her best friend Jo. Dani begins a journey of fixing her vagina and finding someone who'd like to get inside it, all while battling pressures from her parents to find a nice Jewish boy, and her cool sisters who are a constant reminder of everything she has yet to achieve.