Russia, 1875: In Riazan’, Dr Pavlov is summoned to a landowner who refuses to accept the inevitability of his death; to Pavlov’s dismay, he orders the destruction of a beautiful apple orchard. 1894: Experimenting on dogs, Pavlov tries to comprehend the interaction between nerves and external signals governing digestion. In 1904, he formulates the principles of conditional reflexes. When Zvantsev, an opponent of Pavlov’s materialist worldview, leaves the laboratory, the scientist hires Varvara Ivanova who becomes his most reliable assistant. 1912: Pavlov receives an honorary doctorate from Cambridge University. 1917: Despite Pavlov’s political scepticism, the Bolshevik administration treats him with great respect.